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Updated: Jul 10, 2025

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Discovering Genomic Regions Associated with Reproductive Traits and Frame Score in Mexican Simmental and Simbrah

René Calderón-Chagoya1,2, Vicente Eliezer Vega-Murillo3, Adriana García-Ruiz2

  • 1Faculty of Veterinary Medicine and Zootechnics, National Autonomous University of Mexico, Ciudad de México 04510, Mexico.

Genes
|November 25, 2023
PubMed

Keywords:
SimbrahSimmentalgenesgenome-wide association study (GWAS)haplotypessingle nucleotide polymorphism (SNP)

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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