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RNA Splicing in Cancer and Targeted Therapies

Md Rafikul Islam1,2, Preeti Nagar1,2, Shegufta Tasneem Neetole1

  • 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Genes
|November 25, 2023
PubMed

Insights

RNA splicing removes introns from pre-mRNA to create mature mRNA. This crucial process diversifies gene expression and proteomes, impacting development and biology.

Area of Science:

  • Molecular Biology
  • Genetics
  • Gene Expression Regulation

Background:

  • RNA splicing is a fundamental post-transcriptional modification process.
  • It involves the precise removal of introns from precursor messenger RNA (pre-mRNA).
  • This generates mature messenger RNA (mRNA) molecules ready for translation.

Discussion:

  • RNA splicing significantly expands the coding potential of the genome.
  • Alternative splicing generates diverse protein isoforms from a single gene.
  • Dysregulation of splicing is implicated in numerous human diseases.

Key Insights:

  • RNA splicing is a critical regulator of gene expression.
  • It contributes substantially to proteome diversity.
  • The process is vital for normal development and biological functions.

Outlook:

  • Further research into splicing mechanisms can reveal new therapeutic targets.
  • Understanding splicing in disease contexts is crucial for developing targeted treatments.
  • Investigating the interplay between splicing and other gene regulation layers offers future research avenues.

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