Haematological changes induced in the mouse by the isomers of dimethylmyleran and myleran

Both meso and racemic forms of dimethylmyleran are more powerful inhibitors of haematopoiesis than myleran. All produced a characteristic pattern of haematological response in which neutropenia predominated. Myleran exerted its severest depression of neutrophils immediately, whereas the isomers produced maximal damage a week later. Neutropenia induced by the +/- isomer was persistent for 3 weeks.