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Updated: Jul 10, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
Published on: April 23, 2016
The Molecular Impacts of Retrotransposons in Development and Diseases
Phoebe Lut Fei Tam1, Danny Leung1,2
1Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
Abstract:
Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their cis-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chromatin structures. Due to their multifaceted functions, it is crucial for host fitness to maintain strict regulation of these parasitic sequences to ensure proper growth and development. This review explores how subsets of retrotransposons have undergone evolutionary exaptation to enhance the complexity of mammalian genomes. It also highlights the significance of regulating these elements, drawing on recent studies conducted in human and murine systems.
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