Related Experiment Video
Updated: Jul 10, 2025
10:29
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
7.9K
Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention
Dhanya Dharmapalan1, Sushant Satish Mane2
1Apollo Hospitals, Navi Mumbai 400614, India.
Pathogens (Basel, Switzerland)
|November 25, 2023
Summary
Combating drug-resistant tuberculosis in children requires advanced molecular diagnostics and new drugs like bedaquiline. Early detection, child-friendly treatments, and supportive care are vital for successful outcomes in pediatric tuberculosis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Drug-resistant tuberculosis (TB) in children presents significant diagnostic and treatment challenges.
- Mycobacterium tuberculosis (MTB) resistance necessitates updated therapeutic strategies for pediatric populations.
Purpose of the Study:
- To review current advancements in diagnosing and treating drug-resistant TB in children.
- To highlight the importance of novel diagnostics, therapeutics, and supportive care for pediatric TB management.
Main Methods:
- Review of recent literature on molecular diagnostics for TB.
- Analysis of newer antituberculosis drugs, including bedaquiline and delamanid.
- Evaluation of preventive strategies and supportive care in pediatric TB treatment.
Main Results:
- Molecular diagnostics and new drugs enable safer, more convenient child-friendly regimens.
- Preventive strategies and vaccines are under investigation for widespread implementation.
- Psychosocial support, nutritional aid, and monitoring are key to successful treatment.
Conclusions:
- Advancements in diagnostics and therapeutics are improving pediatric drug-resistant TB care.
- Integrated supportive care and ongoing monitoring are essential for optimal treatment outcomes.
- Continued research into preventive measures and vaccines is crucial for future TB control.
Keywords:
TB infectionTB preventive treatmentTB vaccinesXpert MTBbedaquiline (BDQ)delamanid (DLM)latent TBtuberculosisMore Related Videos
Related Concept Videos
01:28Pulmonary Tuberculosis V
181
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
181
01:28Pulmonary Tuberculosis II
242
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
242
01:26Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
01:29Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K
01:28Pneumonia IV: Management
333
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
333