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Related Concept Videos

Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
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Hormonal Regulation of the Menstrual Cycle01:22

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Related Experiment Video

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Using Quantitative Hormone Monitoring to Identify the Postpartum Return of Fertility.

Thomas P Bouchard1, Katherine Schweinsberg2, Amanda Smith2

  • 1Department of Family Medicine, University of Calgary, Calgary, AB T3H 0N9, Canada.

Medicina (Kaunas, Lithuania)
|November 25, 2023
PubMed
Summary

This study found higher luteinizing hormone (LH) thresholds are needed to predict ovulation postpartum. The Mira Analyzer shows distinct fertility return patterns, aiding in pregnancy avoidance strategies.

Keywords:
breastfeedingestrone-3-glucuronideluteinizing hormoneovulationpostpartumpregnanediol glucuronideurine hormone tests

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Area of Science:

  • Reproductive endocrinology
  • Fertility awareness-based methods

Background:

  • The Marquette Method (MM) traditionally uses the ClearBlue Fertility Monitor (CBFM) for postpartum fertility tracking.
  • A new quantitative monitor, the Mira Analyzer, offers potential for more detailed postpartum fertility assessment.

Purpose of the Study:

  • To analyze quantitative hormone data from the Mira Analyzer during the postpartum period.
  • To identify hormone patterns and thresholds predicting ovulation and the return of fertility postpartum.

Main Methods:

  • Retrospective observational case series analyzing Mira Analyzer data (E3G, LH, PDG).
  • Data collected via electronic survey and online portal, including demographics and cycle history.
  • Hormone thresholds were calculated to predict ovulation and identify fertility return patterns.

Main Results:

  • Twenty participants provided data, revealing higher LH thresholds for ovulation triggering postpartum compared to regularly cycling women.
  • Three distinct postpartum fertility return patterns were observed: minimal ovarian activity, follicular activity without ovulation, and early fertility return.
  • Calculated abstinence rates for pregnancy avoidance using experimental thresholds.

Conclusions:

  • Elevated postpartum LH thresholds suggest reduced ovarian responsiveness to pituitary stimulation.
  • The study replicates previously identified postpartum hormone patterns.
  • Larger studies are planned to assess Mira Analyzer effectiveness for postpartum pregnancy avoidance.