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Relationship between Hydration Status and Muscle Catabolism in the Aged Population: A Cross-Sectional Study
Mateu Serra-Prat1,2, Isabel Lorenzo3, Jessica Martínez4
1Research Unit, Consorci Sanitari del Maresme, 08304 Mataró, Barcelona, Spain.
Nutrients
|November 25, 2023
Summary
Dehydration is common in older adults and linked to muscle breakdown, but not directly to sarcopenia. This study highlights the association between dehydration and increased muscle catabolism in the elderly.
Area of Science:
- Gerontology
- Physiology
- Nutritional Science
Background:
- Sarcopenia's underlying mechanisms remain incompletely understood.
- Aging populations face increasing health challenges, including muscle loss.
Purpose of the Study:
- To investigate the link between dehydration and skeletal muscle catabolism.
- To examine the relationship between dehydration, muscle mass, and sarcopenia in older adults.
Main Methods:
- Cross-sectional study of community-dwelling individuals aged 70+.
- Dehydration assessed via plasma osmolarity; body composition by bioimpedance analysis (BIA).
- Sarcopenia diagnosed using EWGSOP-2 criteria; muscle catabolism measured by 3-methyl-histidine (3MH).
Main Results:
- Age correlated positively with plasma osmolarity (r=0.439, p<0.001).
- Plasma osmolarity associated with higher 3MH levels (adjusted beta=0.283, p<0.001), indicating muscle catabolism.
- No correlation found between BIA water content and 3MH; sarcopenic individuals had lower intracellular water percentage.
Conclusions:
- Dehydration is prevalent and increases with age in older adults.
- Dehydration is associated with increased muscle catabolism (3MH).
- The study did not find a direct association between dehydration and sarcopenia itself.
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