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Updated: Jun 29, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Pseudomonas spp. in Canine Otitis Externa.
Bailey Secker1,2, Stephen Shaw1, Robert J Atterbury1
1School of Veterinary Medicine and Science, University of Nottingham, College Road, Sutton Bonington, Leicestershire LE12 5RD, UK.
Canine otitis externa (OE) is often caused by Pseudomonas aeruginosa, which is resistant to antibiotics. New treatments are needed because this pathogen forms biofilms and is hard to eliminate.
Area of Science:
- Veterinary Medicine
- Microbiology
- Infectious Diseases
Background:
- Canine otitis externa (OE) is a prevalent global veterinary issue.
- Pseudomonas aeruginosa is frequently isolated from chronic OE cases, complicating treatment.
- Antibiotic resistance in P. aeruginosa poses a significant challenge to OE recovery.
Purpose of the Study:
- To review the mechanisms of canine OE, focusing on P. aeruginosa.
- To examine the impact of antibiotic resistance on OE treatment outcomes.
- To explore alternative therapies for recalcitrant P. aeruginosa OE.
Main Methods:
- Literature review of studies on canine OE and P. aeruginosa.
- Analysis of P. aeruginosa's biological characteristics and virulence factors.
- Evaluation of antimicrobial resistance patterns and biofilm formation.
Main Results:
- P. aeruginosa is a common cause of difficult-to-treat OE.
- Biofilm formation occurs in 40-95% of P. aeruginosa OE cases.
- Significant intrinsic and acquired antibiotic resistance necessitates alternative treatments.
Conclusions:
- Dysbiosis contributes to P. aeruginosa colonization in canine OE.
- Novel therapeutic strategies are crucial for managing P. aeruginosa OE.
- Bacteriophage therapy shows potential as an alternative treatment.
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