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Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate.
Ramona-Daniela Radu Dusman1, Manuela Elena Voicu1, Mariana Prodana1
1Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
Materials (Basel, Switzerland)
|November 25, 2023
Summary
This study developed electrospun polycaprolactone (PCL) coatings loaded with vancomycin on zirconium (Zr) substrates. These PCL coatings demonstrate corrosion resistance and controlled vancomycin release for potential biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Electrochemistry
Background:
- Polycaprolactone (PCL) is a biodegradable polyester with tunable properties.
- Vancomycin is a critical antibiotic for treating infections.
- Zirconium (Zr) substrates offer biocompatibility and corrosion resistance.
Purpose of the Study:
- To develop and characterize electrospun PCL coatings on Zr substrates.
- To investigate vancomycin loading and release kinetics.
- To evaluate the corrosion resistance and wettability of the coatings.
Main Methods:
- Electrospinning of PCL wires onto Zr substrates.
- Vancomycin loading into PCL coatings.
- Fourier-transform infrared spectroscopy (FT-IR) for structural analysis.
- Scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS) for morphology and composition.
- Wettability, mechanical, and electrochemical tests in simulated body fluid.
Main Results:
- SEM-EDS confirmed the presence of PCL wires with and without vancomycin.
- Electrochemical tests indicated PCL coatings act as a barrier against corrosion.
- Approximately 80% of loaded vancomycin was released within 144 hours, showing a steady release profile after an initial burst.
- A drug release kinetic model was established.
Conclusions:
- Electrospun PCL coatings on Zr substrates are feasible for vancomycin delivery.
- The coatings provide corrosion protection and controlled antibiotic release.
- This approach holds promise for developing advanced antimicrobial medical devices.
