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Drug-Eluting Sutures by Hot-Melt Extrusion: Current Trends and Future Potentials.

Garba M Khalid^1,2, Nashiru Billa³

¹Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Materials (Basel, Switzerland)

|November 25, 2023

Summary

Drug-eluting sutures offer a novel approach to prevent surgical site infections (SSIs) and enhance wound healing. The hot-melt extrusion (HME) technique provides an efficient, eco-friendly method for manufacturing these advanced medical devices.

Keywords:

drug-eluting suture hot-melt extrusion polymer suture production method surgical site infection suture wound healing

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Area of Science:

Biomaterials Science
Surgical Innovation
Drug Delivery Systems

Background:

Surgical site infections (SSIs) often necessitate secondary drug administration, increasing patient burden and healthcare costs.
Current treatments for SSIs and wound healing can involve invasive procedures and foreign materials requiring removal.
Drug-eluting sutures present a promising alternative for localized therapeutic delivery, potentially improving patient outcomes and simplifying post-operative care.

Purpose of the Study:

To review recent advancements in the manufacturing of drug-eluting sutures.
To focus on the application and benefits of the hot-melt extrusion (HME) technique for suture production.
To discuss material requirements, quality attributes, and future directions for drug-eluting sutures.

Main Methods:

Review of recent literature on drug-eluting suture manufacturing.
Focus on the hot-melt extrusion (HME) technique as a solvent-free, continuous manufacturing process.
Exploration of additive manufacturing integration for personalized devices.

Main Results:

Hot-melt extrusion (HME) offers a solvent-free, one-step manufacturing method for drug-eluting sutures, eliminating detrimental drying steps.
HME is environmentally friendly and compatible with biodegradable suture materials.
Integration with additive manufacturing allows for prototyping and scalability of personalized drug-loaded implants.

Conclusions:

Drug-eluting sutures, particularly those manufactured via HME, represent a significant advancement in surgical care.
The HME technique facilitates efficient, eco-friendly production of localized therapeutic delivery systems.
Harmonization of quality assurance by regulatory bodies is crucial for evaluating novel drug-eluting sutures and ensuring patient safety.