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Transition and Post-Transition Radiometals for PET Imaging and Radiotherapy
Caterina Ramogida1,2, Eric Price3
1Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada. caterina_ramogida@sfu.ca.
None:
Radiometals are an exciting class of radionuclides because of the large number of metallic elements available that have medically useful isotopes. To properly harness radiometals, they must be securely bound by chelators, which must be carefully matched to the radiometal ion to maximize radiolabeling performance and the stability of the resulting complex. This chapter focuses on practical aspects of radiometallation chemistry including chelator selection, radiolabeling procedures and conditions, radiolysis prevention, purification, quality control, requisite equipment and reagents, and useful tips.
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