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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: Jul 10, 2025

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

Small Animal Multisubject PET/CT Workflow.

Alexia Kirby^1,2, Adam J Shuhendler^3,4

¹Department of Biology, University of Ottawa, Ottawa, ON, Canada.

Methods in Molecular Biology (Clifton, N.J.)

|November 25, 2023

Summary

Positron emission tomography (PET) imaging offers sensitive molecular insights. This study details using a novel radiotracer, [18F]NA3BF3, for simultaneous dynamic PET scans in mice, targeting aldehydes as biomarkers for disease.

Keywords:

Aldehydes In-vivo imaging PET-CT Positron emission tomography hepatotoxicity

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Area of Science:

Molecular Imaging
Biochemistry
Preclinical Research

Background:

Positron emission tomography (PET) is a sensitive molecular imaging technique.
PET is often combined with CT for anatomical localization.
Aldehyde production increases in various diseases and injuries.

Purpose of the Study:

To describe a method for simultaneous dynamic PET imaging of four mice.
To evaluate the use of the aldehyde-targeted radiotracer [18F]NA3BF3.
To demonstrate the utility of [18F]NA3BF3 in mouse models of hepatotoxicity.

Main Methods:

Dynamic PET imaging of four mice simultaneously.
Utilizing the aldehyde-targeted radiotracer [18F]NA3BF3.
Employing mouse models of hepatotoxicity.

Main Results:

The study outlines a general approach for simultaneous dynamic PET imaging.
Demonstrates the application of [18F]NA3BF3 in preclinical models.
Highlights aldehydes as suitable biomarkers for PET imaging of pathologies.

Conclusions:

Simultaneous dynamic PET imaging of multiple animals is feasible.
[18F]NA3BF3 is a promising radiotracer for detecting upregulated aldehydes.
This approach can advance the study of various diseases and injuries using PET.