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Related Concept Videos

Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

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How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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Age-related decrease in inter-subject similarity of cortical morphology and task and resting-state functional

Junhong Yu1

  • 1Psychology, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue, Singapore, 639798, Singapore. junhong.yu@ntu.edu.sg.

Geroscience
|November 25, 2023
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Summary
This summary is machine-generated.

Older adults are more unique than previously thought, showing greater brain differences. This study reveals age-related divergence in brain structure and function, challenging the myth of homogeneity in aging.

Keywords:
AgingCortical thicknessFunctional connectivityInter-subject similarity

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Area of Science:

  • Neuroscience
  • Gerontology
  • Brain Imaging

Background:

  • The perception of older adults as a homogenous group is a common misconception.
  • Previous research has not fully explored age-related differences in brain structure and function.
  • Understanding individual variability in aging is crucial for personalized medicine and neuroscience.

Purpose of the Study:

  • To investigate age-related divergence in brain structure and function.
  • To challenge the myth of homogeneity in the older adult population.
  • To examine the relationship between cortical thickness and functional connectivity across the lifespan.

Main Methods:

  • Analysis of functional connectivity (FC) using fMRI (2 rest + 5 tasks) and cortical thickness (CT) data.
  • Utilized two lifespan datasets with a total of 1161 participants.
  • Compared between-subject similarity in FC and CT across different age groups.

Main Results:

  • On average, between-subject FC and CT correlations were weaker in older age groups.
  • Brain-wide analyses indicated significant age-related divergence in both structure and function.
  • Cortical thickness similarity predicted functional connectivity similarity, highlighting structure-function coupling.

Conclusions:

  • Findings suggest that older individuals are more dissimilar to their peers than younger individuals.
  • This study debunks the myth that 'all old people are the same,' indicating greater uniqueness in aging.
  • Results have significant implications for neural fingerprinting and understanding brain-behavior associations across the lifespan.