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CXCL9 and NT-proBNP, a notable link between inflammatory mediator and cardiovascular disease biomarker in rheumatoid

Afsaneh Shamsi1, Seyed Askar Roghani1,2,3, Parviz Soufivand3

  • 1Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Clinical Rheumatology
|November 25, 2023
PubMed

Insights

Plasma CXCL9 levels are elevated in rheumatoid arthritis (RA) patients and correlate with cardiovascular disease markers High sensitivity C-reactive protein (HS-CRP) and N-terminal pro-B-type natriuretic peptide (NT-ProBNP). This suggests CXCL9 is a key inflammatory marker in RA.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Cardiovascular disease (CVD) is a critical extra-articular manifestation of rheumatoid arthritis (RA), driven by inflammatory molecules.
  • CXCL9, an inflammatory chemokine, is increasingly recognized for its role in CVD pathogenesis.
  • Understanding the relationship between CXCL9 and cardiac biomarkers in RA is crucial for risk assessment.

Purpose of the Study:

  • To evaluate the association of plasma CXCL9 with established cardiac biomarkers, High sensitivity C-reactive protein (HS-CRP) and N-terminal pro-B-type natriuretic peptide (NT-ProBNP).
  • To compare CXCL9 levels in newly diagnosed RA patients, under-treatment RA patients, and healthy individuals.

Main Methods:

  • Plasma concentrations of CXCL9 and NT-ProBNP were measured using ELISA.
  • HS-CRP levels were determined using latex-enhanced immunoturbidimetric assay.
  • Study included 30 newly diagnosed RA patients, 30 under-treatment RA patients, and 30 healthy controls.

Main Results:

  • RA patients exhibited significantly higher plasma levels of CXCL9, HS-CRP, and NT-ProBNP compared to healthy subjects.
  • Newly diagnosed RA patients showed elevated levels of CXCL9, HS-CRP, and NT-ProBNP compared to under-treatment patients.
  • CXCL9 positively correlated with DAS-28, NT-ProBNP, and HS-CRP in RA patients.

Conclusions:

  • CXCL9 is a significant inflammatory marker in RA, correlating with disease activity (DAS-28).
  • Plasma CXCL9 levels are strongly associated with established cardiovascular biomarkers NT-ProBNP and HS-CRP in RA patients.
  • These findings highlight CXCL9's potential role in RA-associated cardiovascular complications.
Abstract

Keywords:
CXCL9CardiovascularDAS-28HS-CRPNT-proBNPRheumatoid arthritis

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