Related Experiment Video
Updated: Jul 10, 2025
09:16
Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
Published on: August 9, 2019
7.0K
Proteinuria selectivity index in renal disease
Wen Liu1, Zhi-Hang Su1, Qi-Jun Wan1
1Department of Nephrology, the First Affiliated Hospital of Shenzhen University (Shenzhen Second People's Hospital), Shenzhen 518036, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 25, 2023
Summary
The proteinuria selectivity index (PSI) assesses kidney disease by comparing protein clearance, aiding early detection and treatment prediction. This review explores PSI
Area of Science:
- Nephrology
- Clinical Chemistry
- Biomarker Research
Background:
- Early detection of kidney diseases is hindered by testing accessibility.
- Proteinuria selectivity index (PSI) evaluates glomerular permeability changes.
- PSI categorizes proteinuria patterns based on protein clearance rates.
Purpose of the Study:
- To review clinical applications and advancements of PSI in glomerular diseases.
- To compare PSI with existing renal function biomarkers.
- To discuss PSI's future as a predictive marker for biologic therapy response.
Main Methods:
- Review of clinical applications and recent advancements of PSI.
- Comparative analysis of PSI against common renal function biomarkers.
- Exploration of PSI's potential in predicting response to biologics.
Main Results:
- PSI is crucial for kidney disease classification, predicting corticosteroid efficacy, and prognosis.
- The review highlights PSI's role in assessing glomerular permeability.
- PSI demonstrates potential as a predictive marker for targeted therapies.
Conclusions:
- PSI is a valuable tool in managing glomerular diseases.
- Further research can establish PSI as a key predictive biomarker for personalized medicine.
- Advancements in PSI analysis offer improved diagnostic and prognostic capabilities.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
99
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
99
01:28Renal Drug Excretion: Tubular Secretion
192
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
192
01:31Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
238
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
238
01:23Renal Clearance
985
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
985
01:15Drug Elimination by Renal Route: Tubular Secretion
2.4K
Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
2.4K
01:25Renal Drug Excretion: Tubular Reabsorption
189
Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
189