Clinical Interpretation of Intravoxel Incoherent Motion Perfusion Imaging in the Brain

Intravoxel incoherent motion (IVIM) perfusion imaging extracts information on blood motion in biological tissue from diffusion-weighted MR images. The method is attractive from a clinical stand point, because it measures in essence local quantitative perfusion, without intravenous contrast injection. Currently, the clinical interpretation of IVIM perfusion maps focuses on the IVIM perfusion fraction maps, but improvements in image quality of the IVIM pseudo-diffusion maps, using advanced postprocessing tools involving artificial intelligence, could lead to an increased interest in this parameters, as it could provide additional local perfusion information in the clinical setting, not otherwise available with other perfusion techniques.