Cerebrovascular Reserve Imaging: Problems and Solutions

The current standard of practice for assessing patients with cerebrovascular steno-occlusive disease is based on measuring resting blood flow metrics using MR imaging and CT perfusion imaging. However, the reliability of these methods decreases as the degree and number of stenoses increase. The reason for this is that measures of adequate baseline blood flow in highly collateralized circulations do not account for possible shortfalls in recruitable blood flow or increased metabolic demand. The following offers a clinically tested solution for this purpose using cerebrovascular reactivity methodology that applies a quantifiable vasodilatory stimulus improving reproducibility and repeatability essential for optimizing patient management.