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Apparent diffusion coefficient and its standard deviation from diffusion-weighted imaging in preoperative predicting
1Medical Imaging Key Laboratory of Sichuan Province, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Department of Radiology, Meishan Hospital of Traditional Chinese Medicine, Meishan, Sichuan, China.
Clinical Radiology
|November 25, 2023
Summary
Diffusion-weighted imaging (DWI) shows potential for predicting liver invasion in T3-staged gallbladder cancer. Apparent diffusion coefficient (ADC) and its standard deviation (SDADC) metrics aid in preoperative assessment.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Gallbladder carcinoma (GBC) staging is crucial for treatment planning.
- T3-staged GBC requires careful evaluation for potential liver invasion.
- Accurate preoperative assessment of liver invasion is vital for surgical management.
Purpose of the Study:
- To evaluate the efficacy of apparent diffusion coefficient (ADC) and its standard deviation (SDADC) in predicting liver invasion in T3-staged GBC.
- To determine the diagnostic performance of DWI parameters for preoperative liver invasion detection.
Main Methods:
- Forty-one patients with T3-staged GBC underwent diffusion-weighted imaging (DWI) at various b-values (0-1000 s/mm2) using 3T MRI.
- ADC and SDADC were measured in tumor-adjacent and tumor-distant liver tissues.
- Receiver operating characteristic (ROC) curve analysis was used to assess the predictive performance of DWI parameters.
Main Results:
- DWI effectively differentiated patients with and without liver invasion at b-values of 0 and 1000 s/mm2 (AUCs for ADC and SDADC were 0.697 and 0.714, respectively).
- In patients with liver invasion, tumor-adjacent liver tissue showed lower ADC and SDADC compared to distant tissue at b-values of 0, 800, and 1000 s/mm2 (p<0.05).
- The highest AUC for differentiating adjacent from distant liver tissue was 0.731 for SDADC at b-values of 0 and 1000 s/mm2.
Conclusions:
- Diffusion-weighted imaging (DWI) demonstrates potential value in the preoperative prediction of liver invasion in T3-staged gallbladder carcinoma.
- ADC and SDADC derived from DWI can serve as useful biomarkers for assessing liver invasion.
- Further research may refine DWI techniques for improved accuracy in GBC staging.
