Related Experiment Video
Updated: Jul 10, 2025
Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo
Robert M DiBlasi1,2, Kellie J Micheletti3, Tina Romo4
1Center for Respiratory Biology and Therapeutics, Seattle Children's Research Institute, Seattle, WA, USA. robert.diblasi@seattlechildrens.org.
Objective:
To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.
Study Design:
Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (n = 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.
Results:
Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO2, and lower PaCO2 after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (-17.4% from baseline before lavage) compared to variable SP (-44.9%).
Conclusion:
HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV.
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