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Updated: Jul 10, 2025

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Late-Stage Peptide Modification Via Aspartic Acid as Endogenous Directing Group
1School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Abstract:
Polypeptide drugs have become one of the most crucial tools in drug research and other related fields because of their high pharmacological activity, low dosage, low toxicity and side effects. However, the problems of poor metabolic stability, short half-value period and difficulty in penetration have greatly limit the development of new polypeptide drugs rendering the functional modification of peptides a crucial tool to polypeptide drugs. In this paper, we developed a new strategy for peptide functionalization through the usage of aspartic acid side chain as an endogenous directing group to realize polypeptide's selective bond arylation.
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