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Updated: Jul 10, 2025
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Exploring Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity: An Emerging Issue from Bench to Bedside]
Debora Collotta1, Eleonora Aimaretti2, Massimo Collino1
1Department of Neuroscience "Rita Levi-Montalcini", University of Turin, Turin, Italy.
Abstract:
Tyrosine Kinase Inhibitors (TKIs) have significantly contributed to revolutionizing cancer treatment, as they are orally administered small molecules able to target key pathways involved in tumor growth and angiogenesis. However, the clinical utility of TKIs may be compromised by adverse effects, which can affect tissues and organs, including kidneys. This comprehensive review offers a general overview of studies reporting the incidence and clinical characteristics of TKI-related nephrotoxicity and it explores the mechanisms underlying the intricate relationship between TKIs and renal toxicity. The biological rationale for the kidney manifestations of toxicity associated with TKI agents is here discussed, underlying potential off-target effects and emphasizing the importance of accurate risk assessment and tailored patient management strategies. Deep insight into the molecular mechanisms of TKI nephrotoxicity will help to improve the global understanding of the pathophysiology of this peculiar toxicity and to develop more effective and safer therapies.
Insights
Tyrosine Kinase Inhibitors (TKIs) revolutionize cancer therapy but can cause kidney damage (nephrotoxicity). Understanding TKI mechanisms and patient risk is crucial for safer cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Nephrology
Context:
- Tyrosine Kinase Inhibitors (TKIs) are oral small molecules targeting cancer growth and angiogenesis.
- Adverse effects of TKIs can impact various organs, notably the kidneys, leading to nephrotoxicity.
- Clinical management of TKIs necessitates understanding their renal toxicity profile.
Purpose:
- To provide a comprehensive overview of TKI-related nephrotoxicity incidence and clinical features.
- To explore the underlying mechanisms of kidney damage caused by TKIs.
- To discuss the biological rationale and potential off-target effects contributing to TKI nephrotoxicity.
Summary:
- This review examines studies on TKI nephrotoxicity, detailing its occurrence and clinical presentation.
- It delves into the molecular mechanisms linking TKIs to renal toxicity, including off-target effects.
- The importance of risk assessment and personalized management for TKI-treated patients is highlighted.
Impact:
- Enhancing the understanding of TKI nephrotoxicity pathophysiology.
- Informing the development of safer and more effective TKI therapies.
- Guiding clinical strategies for managing TKI-induced kidney damage.
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