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Differences in the androgen response between two mouse species.

P W Houben, L P Bullock, T O Fox

    Biochemical Genetics
    |December 1, 1986
    PubMed
    Summary
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    Differences in how male hormones (androgens) affect kidney function were found between two mouse species. This suggests genetic differences, not receptor issues, control androgen action in the kidney.

    Area of Science:

    • Comparative genomics
    • Endocrinology
    • Molecular biology

    Background:

    • Androgens influence kidney function in Mus musculus, affecting parameters like renal weight and beta-glucuronidase activity.
    • Sexual dimorphism in these androgen-responsive parameters was not observed in Mus caroli, suggesting species-specific regulation.
    • This difference was not due to a general lack of androgen action or significant defects in androgen receptors.

    Purpose of the Study:

    • To investigate the reasons for the lack of renal androgen responsiveness in Mus caroli compared to Mus musculus.
    • To determine if differences in androgen receptor characteristics or specific renal endpoints account for the observed variation.
    • To explore the molecular mechanisms underlying differential androgen action in the kidney between these two species.

    Main Methods:

    Related Experiment Videos

    • Analysis of renal androgen receptor characteristics in Mus musculus and Mus caroli using two distinct methods.
    • Comparison of androgen receptor properties in brain tissue between the two species.
    • Assessment of ornithine decarboxylase activity as a renal androgen-responsive endpoint in Mus caroli.

    Main Results:

    • Minor differences were detected in the characteristics of renal androgen receptors between Mus musculus and Mus caroli.
    • These minor receptor differences were deemed insufficient to explain the lack of androgen responsiveness in Mus caroli kidneys.
    • No significant differences in brain androgen receptors were found between the species.
    • Ornithine decarboxylase activity was identified as an androgen-responsive endpoint in Mus caroli kidneys.

    Conclusions:

    • The control of renal androgen action differs between Mus musculus and Mus caroli at the level of genetic regulatory elements.
    • Species-specific genetic regulation, rather than androgen receptor variations, underlies the differential response of kidney endpoints to androgens.
    • Further research into genetic regulatory elements is warranted to understand interspecies differences in hormone action.