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Higher plasma aldosterone concentrations in patients with aortic diseases and hypertension: a retrospective
Yuting Pu1,2, Guifang Yang1,2, Xiaogao Pan1,2
1Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, 410011, Hunan, China.
Insights
Hypertension patients with aortic disease show higher plasma aldosterone concentration (PAC). This study explored the link between PAC and aortic conditions in hypertensive individuals, suggesting elevated PAC in those with aortic disease.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Hypertension Research
Background:
- Aortic diseases represent a significant vascular health risk.
- The connection between plasma aldosterone concentration (PAC) and aortic diseases is underexplored.
- This study investigates PAC differences in hypertensive patients with and without aortic disease.
Purpose of the Study:
- To determine if plasma aldosterone concentration (PAC) differs between hypertensive patients with and without aortic disease.
- To explore the association between PAC and aortic conditions in a hypertensive cohort.
Main Methods:
- Analysis of 926 hypertensive patients' electronic health records, including PAC measurements.
- Inclusion/exclusion criteria defined case and control groups.
- Multivariate logistic regression and propensity score matching were used to analyze PAC differences and control for confounders.
Main Results:
- 394 participants (66 with aortic disease) were analyzed.
- Hypertensive patients with aortic disease showed a higher likelihood of elevated PAC (OR=1.138).
- This association persisted after controlling for confounding factors and via propensity score matching.
Conclusions:
- Primary hypertensive patients with aortic diseases exhibit elevated plasma aldosterone concentration (PAC).
- Further research is needed to establish a causal relationship between PAC and aortic disease.
Background:
Aortic diseases remain a highly perilous macrovascular condition. The relationship between circulating aldosterone and aortic diseases is rarely explored, thus we investigated the difference in plasma aldosterone concentration (PAC) between patients with and without aortic disease in hypertensive people.
Methods:
We analyzed 926 patients with hypertension, ranging in age from 18 to 89 years, who had their PAC measured from the hospital's electronic database. The case group and control group were defined based on inclusion and exclusion criteria. The analysis included general information, clinical data, biochemical data, and medical imaging examination results as covariates. To further evaluate the difference in PAC between primary hypertension patients with aortic disease and those without, we used multivariate logistic regression analysis and also employed propensity score matching to minimize the influence of confounding factors.
Results:
In total, 394 participants were included in the analysis, with 66 individuals diagnosed with aortic diseases and 328 in the control group. The participants were predominantly male (64.5%) and over the age of 50 (68.5%), with an average PAC of 19.95 ng/dL. After controlling for confounding factors, the results showed hypertension patients with aortic disease were more likely to have high PAC levels than those without aortic disease (OR = 1.138, 95% CI [1.062 to 1.238]). Subgroup analysis revealed consistent relationship between PAC and primary hypertensive patients with aortic disease across the different stratification variables. Additionally, hypertensive patients with aortic disease still have a risk of higher PAC levels than those without aortic disease, even after propensity score matching.
Conclusions:
The results of this study suggest that primary hypertensive patients with aortic diseases have elevated levels of PAC, but the causal relationship between PAC and aortic disease requires further study.
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