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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

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The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
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Related Experiment Video

Updated: Jul 10, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Exploiting innate immunity for cancer immunotherapy.

Ming Yi1,2, Tianye Li3, Mengke Niu4

  • 1Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, People's Republic of China.

Molecular Cancer
|November 26, 2023
PubMed
Summary

Harnessing innate immunity, beyond adaptive T cell responses, offers new cancer treatment avenues. Strategies targeting innate immune cells show promise for improving cancer immunotherapy efficacy.

Keywords:
Cancer immunotherapyChimeric antigen receptorDendritic cellInnate immunityMacrophageMyeloid-derived suppressor cellNatural killer cellNeutrophil

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Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Current cancer immunotherapies primarily focus on adaptive immunity, yielding limited patient benefits.
  • Tumor microenvironment components beyond adaptive immunity significantly influence immunotherapy outcomes.
  • Innate immune cells play crucial roles in cancer immune evasion and surveillance.

Purpose of the Study:

  • To review the role of innate immune cells in antitumor immunity.
  • To discuss novel therapeutic strategies targeting the innate immune system for cancer control.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Summary of recent advances in innate arm-targeted therapies.

Main Results:

  • Innate immune cells (macrophages, NK cells, etc.) are critical in antitumor responses.
  • Emerging strategies like STING agonists and CAR-based innate cell therapies demonstrate potent antitumor activity.
  • Metabolic regulators and new immune checkpoint inhibitors targeting innate immunity are under investigation.

Conclusions:

  • Targeting innate immunity presents a promising frontier for enhancing cancer immunotherapy.
  • Exploiting innate immune cells offers potential therapeutic options for a broader range of cancer patients.