Signaling pathways and targeted therapies for psoriasis

Area of Science:

• Dermatology
• Immunology
• Genetics

Background:

• Psoriasis is a prevalent, chronic, inflammatory skin condition with significant global health and societal impact.
• While immunological understanding has advanced psoriasis treatment, mechanisms of rarer forms and disease recurrence remain unclear.
• Addressing severe adverse effects and treatment cessation challenges is crucial for comprehensive psoriasis management.

Purpose of the Study:

• To provide a comprehensive overview of psoriasis, including epidemiology, clinical subtypes, pathophysiology, and comorbidities.
• To systematically discuss signaling pathways, extracellular cytokines, and intracellular transmission involved in psoriasis pathogenesis.
• To explore potential metabolic, epigenetic, and molecular mechanisms underlying psoriasis and its comorbidities, and disease recurrence.

Main Methods:

• Literature review and systematic discussion of existing research on psoriasis.
• Analysis of signaling pathways, including extracellular cytokines and intracellular transmission.
• Exploration of metabolic, epigenetic, and molecular cascades related to psoriasis and its comorbidities.

Main Results:

• Psoriasis pathogenesis involves complex extracellular and intracellular signaling pathways.
• Metabolic and epigenetic factors likely play significant roles in psoriasis development and progression.
• Current treatments, particularly targeted therapies, offer progress, but disease recurrence mechanisms require further elucidation.

Conclusions:

• A deeper understanding of psoriasis pathogenesis, including less common forms and recurrence, is essential for advancing therapeutic strategies.
• Investigating metabolic and epigenetic mechanisms may reveal novel therapeutic targets.
• Further research into disease recurrence is critical for improving long-term patient outcomes and expanding clinical options.