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Related Experiment Videos

Sickle cell membranes and oxidative damage.

C Rice-Evans, S C Omorphos, E Baysal

    The Biochemical Journal
    |July 1, 1986
    PubMed
    Summary
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    Sickle cell disease involves oxidative damage to red blood cells, linked to irreversibly sickled cells. Antioxidants and iron chelators suggest oxidized hemoglobin contributes to this sickle cell pathology.

    Area of Science:

    • Hematology
    • Biochemistry
    • Pathology

    Background:

    • Sickle erythrocytes are prone to oxidative damage.
    • This damage correlates with irreversibly sickled cells.

    Purpose of the Study:

    • To investigate the role of oxidative stress in sickle cell disease pathology.
    • To identify the contribution of membrane-bound hemoglobin oxidation products.

    Main Methods:

    • Assessing oxidative damage in sickle erythrocytes.
    • Evaluating the effects of antioxidants, free radical scavengers, and iron chelators.
    • Correlating oxidative stress with irreversibly sickled cells.

    Main Results:

    • Incubation-induced oxidative stress was suppressed by antioxidants, free radical scavengers, and an iron chelator.

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  • Oxidative damage in sickle erythrocytes is a significant factor.

    • Conclusions:

    • Oxidation products of membrane-bound hemoglobin likely contribute to sickle cell disease pathology.
    • Targeting oxidative stress may be a therapeutic strategy for sickle cell disease.