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The Association of Bone Turnover Markers with Muscle Function, Falls, and Frailty in Older Women in Long-Term Care
N S Haeri1, S Perera, S L Greenspan
1Nami Safai Haeri, MD, 3471 Fifth Ave, Suite 1110, Pittsburgh, PA, USA 15213, Telephone: (412) 692-2472,
Background:
Osteoporosis and sarcopenia commonly coexist in older adults. There is strong evidence that bone and muscle impact each other through mechanical and biochemical cross-talk.
Objectives:
We sought to investigate the relationship between the markers of bone remodeling including the C-terminal telopeptide of type 1 collagen (CTX) and procollagen type 1 N propeptide (P1NP) with muscle function, falls, and frailty in older women residing in long-term care (LTC) facilities.
Design:
A secondary analysis of a randomized controlled trial.
Setting:
Residents of LTC.
Participants:
One hundred seventy-eight older women with osteoporosis.
Measurements:
We measured and analyzed baseline CTX, P1NP, gait speed, sit to stand time, history of falls, and frailty index.
Results:
Participants had a mean age of 86.7 years and BMI of 27.6 kg/m2. The correlation (r) of CTX with gait speed and sit to stand test, as indices for muscle function, were -0.193 (p=0.0163) and 0.152 (p=0.0507), respectively. Additionally, CTX level was significantly associated with history of falls (p=0.0068), recurrent falls (p=0.0260), and frail phenotype (p=0.0126). P1NP did not have a significant association with gait speed, sit to stand test, and history of falls; however, it was associated with frail phenotype (p=0.0137). Most findings persisted after adjusting for age.
Conclusions:
In older women residing in LTC facilities, CTX was associated with gait speed, falls history, and frail phenotype, whereas P1NP was only associated with frail phenotype. These findings suggest a relationship between bone remodeling and muscle function.
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