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Updated: Jul 10, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Role of epithelial-mesenchymal transition factor SNAI1 and its targets in ovarian cancer aggressiveness
Tise Suzuki1, Ashlyn Conant1, Casey Curow1,2
1Division of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Abstract:
Ovarian cancer remains the most lethal gynecologic malignancy in the USA. For over twenty years, epithelial-mesenchymal transition (EMT) has been characterized extensively in development and disease. The dysregulation of this process in cancer has been identified as a mechanism by which epithelial tumors become more aggressive, allowing them to survive and invade distant tissues. This occurs in part due to the increased expression of the EMT transcription factor, SNAI1 (Snail). In the case of epithelial ovarian cancer, Snail has been shown to contribute to cancer invasion, stemness, chemoresistance, and metabolic changes. Thus, in this review, we focus on summarizing current findings on the role of EMT (specifically, factors downstream of Snail) in determining ovarian cancer aggressiveness.
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