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Neuromodulation for Gastroesophageal Reflux Disease: A Systematic Review
Jia Yi Woo1, Victor Pikov2, Jiande D Z Chen3
1Northern Health, Epping, Victoria, Australia.
Journal of Translational Gastroenterology
|November 27, 2023
Summary
Neuromodulation therapies, including electrical stimulation, acustimulation, and acupuncture, effectively treat gastroesophageal reflux disease (GERD) symptoms and underlying causes. These methods offer safe, individualized treatment options for GERD patients.
Area of Science:
- Gastroenterology
- Neurology
- Medical Devices
Background:
- Gastroesophageal reflux disease (GERD) affects millions globally, necessitating novel therapeutic approaches.
- Understanding the mechanisms and efficacy of neuromodulation for GERD is crucial for advancing patient care.
Purpose of the Study:
- To systematically review the efficacy, mechanisms, and safety of three neuromodulation therapies for GERD.
- To evaluate the impact of these therapies on GERD symptoms and key pathophysiological factors.
Main Methods:
- Systematic literature review adhering to PRISMA guidelines.
- Searched Medline, Embase, and PubMed databases; assessed studies using Covidence software.
- Included 13 clinical studies evaluating LES electrical stimulation, transcutaneous electrical acustimulation, and manual acupuncture.
Main Results:
- All neuromodulation therapies demonstrated significant improvements in GERD symptoms.
- Electrical stimulation increased lower esophageal sphincter (LES) pressure; acustimulation improved esophageal and gastric motility and parasympathetic activity.
- No severe adverse effects were reported for any of the evaluated neuromodulation methods.
Conclusions:
- Neuromodulation therapies are effective in managing GERD symptoms and addressing underlying pathophysiological mechanisms.
- These therapies represent valuable, safe options for personalized GERD treatment strategies.
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