Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

6.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
6.2K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.5K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of GIP and GLP-1 infusion on bone resorption in glucose intolerant, pancreatic insufficient cystic fibrosis.

Journal of clinical & translational endocrinology·2025
Same author

The relationship between food selectivity and stature in pediatric patients with avoidant-restrictive food intake disorder - an electronic medical record review.

Journal of eating disorders·2024
Same author

The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2023
Same author

Bone health in avoidant/restrictive food intake disorder: a narrative review.

Journal of eating disorders·2023
Same author

Bone resorption and incretin hormones following glucose ingestion in healthy emerging adults.

Journal of clinical & translational endocrinology·2023
Same author

Cardiometabolic Risk and Its Relationship With Visceral Adiposity in Children With Cerebral Palsy.

Journal of the Endocrine Society·2023

Related Experiment Video

Updated: Jul 10, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K

Bone mass accrual in children.

Eugene Rodrick1, Joseph M Kindler

  • 1University of Georgia, Department of Nutritional Sciences, Athens, Georgia, USA.

Current Opinion in Endocrinology, Diabetes, and Obesity
|November 27, 2023
PubMed
Summary

Childhood bone accrual is vital for peak bone mass, influencing future osteoporosis risk. Factors like genetics, diet, and physical activity play key roles, with advanced imaging aiding research.

Area of Science:

  • Pediatric Bone Health
  • Skeletal Development
  • Osteoporosis Prevention

Background:

  • Bone accrual during childhood and adolescence is critical for achieving peak bone mass.
  • Peak bone mass is a significant determinant of osteoporosis risk later in life.
  • Both nonmodifiable (genetics, sex, race) and modifiable (physical activity, diet) factors influence bone mass accrual.

Conclusions:

  • Understanding bone accrual patterns is essential for optimizing peak bone mass.
  • Longitudinal studies using novel imaging are needed to fully elucidate factors in peak bone strength attainment and maintenance.
  • This review highlights key aspects of pediatric bone health and assessment strategies.

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.4K
Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.1K

Related Experiment Videos

Last Updated: Jul 10, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.4K
Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.1K