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Updated: Jul 10, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Experimental rat models for Hashimoto's thyroiditis.

L Beduleva1,2, A Sidorov3,4, K Fomina3,4

  • 1Laboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St., Izhevsk, Russian Federation, 426034. lvbeduleva@gmail.com.

Journal of Endocrinological Investigation
|November 27, 2023
PubMed
Summary

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This summary is machine-generated.

Researchers developed two rat models for autoimmune thyroiditis, a condition similar to Hashimoto's thyroiditis. Immunizing rats with thyroglobulin successfully induced experimental autoimmune thyroiditis, offering a new model for studying the disease.

Area of Science:

  • Immunology
  • Endocrinology
  • Pathology

Background:

  • Hashimoto's thyroiditis (HT) is an autoimmune disease targeting thyroid follicles.
  • Developing an effective experimental model for HT is crucial for studying its pathogenesis and testing new treatments.
  • Current models often require specific genetic sensitivities or enhancing agents.

Purpose of the Study:

  • To establish experimental autoimmune thyroiditis (EAT) models in Wistar rats without genetic manipulation or adjuvants.
  • To determine if thyroglobulin (Tg) injection alone can induce a condition resembling human Hashimoto's thyroiditis.
  • To evaluate the characteristics of induced EAT and potential associated pathologies.

Main Methods:

  • Wistar rats were immunized with either rat thyroglobulin (Tg) or porcine Tg.
Keywords:
Experimental autoimmune thyroiditisOxyphil cell metaplasiaParathyroid glandsPorcine thyroglobulinRat thyroglobulinTotal serum calcium

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  • Thyroid and parathyroid glands were histologically examined after 8 weeks.
  • Thyroid function and serum calcium levels were assessed.

    • Main Results:

    • Both rat and porcine Tg induced lymphocytic infiltration, follicle atrophy, and degradation in rat thyroids.
    • Porcine Tg induced a more severe EAT compared to rat Tg.
    • Parathyroid oxyphilic metaplasia and hypocalcemia were observed in rats immunized with porcine Tg.

    Conclusions:

    • Two distinct rat models of autoimmune thyroiditis were successfully generated.
    • Rat Tg-induced EAT serves as a viable model for Hashimoto's thyroiditis.
    • Porcine Tg-induced EAT presents additional parathyroid and calcium metabolic changes.