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Updated: Jul 10, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
A dynamic perspective on depressive symptoms during the first year postpartum.
Laura K Winstone-Weide1, Jennifer A Somers2, Sarah G Curci1
1Department of Psychology, Arizona State University.
Postpartum depressive (PPD) symptoms fluctuate significantly in the first year. Higher prenatal risk and infant negativity predict more PPD symptom variability and intensity, but not symptom carryover.
Area of Science:
- Psychology
- Perinatal Mental Health
- Developmental Psychology
Background:
- Postpartum depression (PPD) is a significant concern affecting maternal mental health.
- Understanding the dynamic nature of PPD symptoms and their predictors is crucial for timely intervention.
Purpose of the Study:
- To characterize intraindividual variability in postpartum depressive symptoms over the first year postpartum.
- To identify maternal and infant factors predicting differences in this variability.
Main Methods:
- Utilized dynamic structural equation modeling with multilevel location scale analyses.
- Assessed 322 low-income Mexican-origin mothers across 11 time points from 3 weeks to 1 year postpartum.
- Measured prenatal cumulative risk, infant temperamental negativity, and prenatal depressive symptoms.
Main Results:
- Postpartum depressive symptoms exhibited significant within-mother volatility, showing substantial ebbs and flows.
- Mothers with more negative infants and higher prenatal cumulative risk showed higher average PPD symptom levels and greater volatility.
- These factors did not influence the carryover of symptoms from one time point to the next.
Conclusions:
- Intraindividual variability in postpartum depressive symptoms is a key feature of the first year postpartum.
- Prenatal risk and infant temperament are significant predictors of the intensity and fluctuation of PPD symptoms.
- These findings highlight the dynamic nature of PPD and the importance of considering maternal and infant factors.
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