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Related Experiment Video

Updated: Jul 10, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Association between interleukin-6 and preterm birth: a meta-analysis.

Ying Chang^1,2, Wen Li^1,2, Yongmei Shen^1,2

¹Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Obstetrics Gynecology, Tianjin, China.

Annals of Medicine

|November 27, 2023

Summary

Interleukin-6 (IL-6) levels in amniotic and cervicovaginal fluid are linked to preterm birth (PTB). This meta-analysis suggests IL-6 may aid in predicting PTB, especially spontaneous PTB.

Keywords:

Meta-Analysis Preterm birth amniotic fluid cervicovaginal fluid interleukin-6

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Last Updated: Jul 10, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Published on: August 12, 2020

Area of Science:

Reproductive biology
Immunology
Obstetrics

Background:

Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in preterm birth (PTB).
Previous meta-analyses have yielded inconclusive results regarding the association between IL-6 and PTB.
This study provides an updated meta-analysis to clarify the IL-6 and PTB relationship.

Conclusions:

IL-6 levels in amniotic fluid and cervicovaginal fluid show potential as predictive biomarkers for preterm birth.
The findings suggest specific IL-6 measurement sites are more informative for PTB prediction.
Further research may validate IL-6's role in clinical PTB prediction strategies.