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Extreme Reticulocytosis After Splenectomy in a Patient With Hemoglobin Mizuho
Helene Narvestad-Bøttger1, Anne Winther-Larsen2, Jens Haugbølle Bjerre3
1Department of Clinical Genetics.
Background:
Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions.
Observations:
Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×10 9 /L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count.
Conclusions:
We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...