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Central nervous system infection in a pediatric population in West Java

Dewi H Alisjahbana1, Syndi Nurmawati2, Mia Milanti1

  • 1Department of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Plos Neglected Tropical Diseases
|November 27, 2023
PubMed

Insights

Pediatric central nervous system (CNS) infections in Indonesia revealed common causes like cytomegalovirus and Streptococcus pneumoniae. This study emphasizes diverse diagnostic methods for identifying CNS pathogens in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Neurovirology
  • Clinical Microbiology

Background:

  • Central nervous system (CNS) infections pose significant risks to children's health, particularly in developing nations.
  • Limited etiological data exists for pediatric CNS infections in Indonesia, hindering effective treatment and prevention.

Purpose of the Study:

  • To investigate the causes of CNS infections in a pediatric cohort in Bandung, West Java.
  • To identify common viral and bacterial pathogens responsible for CNS infections in Indonesian children.

Main Methods:

  • Analysis of cerebrospinal fluid and serum samples from 50 pediatric patients admitted between 2017-2018.
  • Utilized molecular, serological, and virus isolation techniques for comprehensive pathogen detection.

Main Results:

  • Identified causal pathogens in 20% (10/50) of cases.
  • Key pathogens included cytomegalovirus (4), Streptococcus pneumoniae (2), tuberculosis (2), Salmonella Typhi (1), and dengue virus (1).

Conclusions:

  • Highlights the necessity of employing a broad spectrum of diagnostic methods for accurate CNS pathogen identification.
  • Underscores the challenges in determining CNS infection etiology in pediatric populations within resource-limited laboratory settings.

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