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Chimeric Antigen Receptor (CAR) T-Cell Products for Pediatric Cancers: Why Alternative Development Paths Are Needed

Claudia Rossig1,2, Andrew D Pearson3, Gilles Vassal3,4

  • 1Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|November 27, 2023
PubMed
Abstract

No abstract available in PubMed .

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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