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TGF-β3 mediates mitochondrial dynamics through the p-Smad3/AMPK pathway

Xinmei Du1, Mengmeng Duan1, Shiyi Kan1

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Cell Proliferation
|November 27, 2023
PubMed
Summary

Transforming growth factor-beta 3 (TGF-β3) promotes mitochondrial fission in chondrocytes, increasing mitochondrial numbers. This process is mediated by the AMPK signaling pathway, offering potential therapeutic strategies for osteoarthritis.

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