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Single VHH-directed BCMA CAR-NK cells for multiple myeloma

Quan Ren1, Yingling Zu1, Hongchang Su2

  • 1Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, 450008, China.

Experimental Hematology & Oncology
|November 28, 2023
PubMed
Summary

Engineered natural killer (NK) cells targeting BCMA show potent anti-myeloma activity. BCMA-CD28-IL15 CAR-NK cells demonstrate superior efficacy and prolonged survival in a mouse model, offering a promising immunotherapy approach.

Keywords:
BCMACAR-NKMultiple MyelomaVHH

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