Related Experiment Video
Updated: Jul 9, 2025
04:36
Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
Published on: January 19, 2024
4.1K
[Infections and male infertility]
F Saint1, E Huyghe2, C Methorst3
1Service d'urologie-transplantation, CHU Amiens Picardie, Amiens, France; Laboratoire EPROAD EA 4669, université Picardie Jules-Verne, Amiens, France.
Summary
Urogenital infections are a frequent cause of male infertility. Early diagnosis and tailored treatment of these infections can significantly improve male fertility outcomes.
Area of Science:
- Reproductive Medicine
- Urology
- Infectious Diseases
Background:
- The link between urogenital infections and male infertility is a complex and debated topic.
- Infectious causes are among the most common treatable factors contributing to male infertility.
Approach:
- A comprehensive literature review of 189 English-language human studies published before May 2023 was conducted.
- Systematic search strategies including clinical history, physical examination, ultrasound, and bacteriological testing are recommended for diagnosing urogenital infections.
Key Points:
- Urogenital infections, primarily bacterial or viral, can affect the seminal tract, accessory glands, and testicles.
- These infections lead to inflammation, increased oxidative stress, altered spermogram parameters, and increased sperm DNA fragmentation, negatively impacting male fertility.
- Prompt identification and management of infectious agents are crucial for optimizing prognosis.
Conclusions:
- Accurate diagnosis of the infection's extent is essential for urologists.
- Developing patient-tailored therapeutic strategies is key to improving male fertility.
Related Concept Videos
01:23Infertility in Males
270
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
270
01:26Sexually Transmitted Infections
321
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
321
01:20Disorders of the Male Reproductive System
424
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
424
01:41Spermatogenesis
102.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.6K
01:28Infertility in Females
311
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
311
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K