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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jul 9, 2025

Basophil Activation Test for Allergy Diagnosis
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Allergen Immunotherapy for Asthma.

Jasper H Kappen1, Ioana Agache2, Marek Jutel3

  • 1Department of Pulmonology, STZ Centre of Excellence for Asthma, COPD and Respiratory Allergy, Franciscus & Vlietland, Rotterdam, The Netherlands; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

The Journal of Allergy and Clinical Immunology. in Practice
|November 28, 2023
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy effectively treats IgE-mediated allergies and allergic rhinitis. Emerging evidence supports its role in improving asthma control, leading to its recognition as an add-on therapy for mild/moderate asthma.

Keywords:
AllergyClinicalImmunotherapySCITSLITTreatment

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Area of Science:

  • Immunology
  • Allergy Research
  • Respiratory Medicine

Background:

  • Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergies.
  • It effectively reduces disease burden and symptoms in allergic rhinitis patients, with or without asthma.
  • International guidelines now recognize AIT as an add-on therapy for mild/moderate allergic asthma.

Purpose of the Study:

  • To review the current evidence on allergen immunotherapy for allergic asthma.
  • To highlight the role of AIT in achieving asthma control.
  • To discuss the progress and limitations in biomarker development for AIT in asthma.

Main Methods:

  • Literature review of studies on allergen immunotherapy in allergic asthma.
  • Analysis of international guidelines and expert recommendations.
  • Evaluation of current research on biomarkers for patient selection and efficacy.

Main Results:

  • Allergen immunotherapy demonstrates potential in facilitating asthma control.
  • International bodies acknowledge AIT as an add-on treatment for mild/moderate asthma.
  • Promising developments in biomarkers exist but require further data.

Conclusions:

  • Allergen immunotherapy is a valuable treatment option for allergic asthma.
  • Further research is needed to optimize patient selection and evaluate efficacy using biomarkers.
  • Continued investigation into AIT's role in respiratory diseases is warranted.