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Updated: Jul 9, 2025

A High-content Assay for Monitoring AMPA Receptor Trafficking
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A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

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C4 induces pathological synaptic loss by impairing AMPAR trafficking.

Rhushikesh A Phadke1, Ezra Kruzich2, Luke A Fournier2

  • 1Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA, USA.

Biorxiv : the Preprint Server for Biology
|November 28, 2023
PubMed
Summary

Overexpression of the schizophrenia-associated gene C4 causes synaptic loss independently of the complement receptor 3 pathway. This occurs via intracellular GluR1 degradation, a process that can be reversed by increasing SNX27 levels.

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