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Updated: Jul 9, 2025
10:10
Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
21.9K
Lymphatic muscle cells are unique cells that undergo aging induced changes
Biorxiv : the Preprint Server for Biology
|November 28, 2023
Summary
This study maps the gene expression of lymphatic muscle cells (LMCs) in aging mice. Findings reveal how inflammation impacts LMC function and identify potential targets for lymphedema treatments.
Area of Science:
- Vascular Biology
- Molecular Biology
- Immunology
Background:
- Lymphatic muscle cells (LMCs) drive lymph transport, crucial for fluid balance and immunity.
- LMC dysfunction is linked to various diseases, yet their transcriptional profiles remain largely unknown.
- Understanding LMC gene expression is vital for addressing lymphatic disorders.
Approach:
- Generated a single-cell transcriptional atlas of mouse dermal collecting lymphatic vessels across different ages.
- Identified unique genes defining LMCs and characterized age-related transcriptomic and phenotypic changes.
- Investigated the role of the microenvironment in LMC function, particularly in aged vessels.
Key Points:
- Discovered genes distinguishing LMCs from other muscle cell types.
- Documented phenotypical and transcriptomic alterations in LMCs from aged lymphatic vessels.
- Uncovered a pro-inflammatory microenvironment that impairs the contractile function of aged LMCs.
Conclusions:
- Provides a comprehensive transcriptional resource for LMCs.
- Offers insights into LMC aging and inflammation-induced dysfunction.
- Facilitates drug target identification for preserving lymphatic function and understanding lymphedema.
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