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Delivery mode impacts gut bacteriophage colonization during infancy.

Poorani Subramanian¹, Hector N Romero-Soto¹, David B Stern¹

¹National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.

Medrxiv : the Preprint Server for Health Sciences

|November 28, 2023

Summary

Delivery mode significantly impacts gut bacteriophage (virus that infects bacteria) colonization in infants. Vaginal delivery promotes greater bacteriophage diversity and function, potentially influencing immune development.

Keywords:

bacteriophages cesarean section delivery mode infant microbiome vaginal delivery virome

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Area of Science:

Microbiome research
Virology
Immunology

Background:

Cesarean section delivery alters infant gut bacterial colonization, impacting immune health.
Gut bacteriophages influence microbiome composition and host immune responses.
The effect of delivery mode on infant bacteriophage colonization is largely unknown.

Conclusions:

Delivery mode shapes bacteriophage colonization and function in early life.
Bacteriophages may play a role in the inflammatory and immune outcomes associated with delivery mode.
Future studies should consider bacteriophages and transkingdom interactions when examining delivery mode's impact on infant health.