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Updated: Jul 9, 2025
05:52
Hyponeophagia: A Measure of Anxiety in the Mouse
Published on: May 17, 2011
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Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status
Torsten Klengel1, Shu Dan2, Julia Hall2
1McLean Hospital.
Research Square
|November 28, 2023
Summary
This study explored gene expression in Major Depressive Disorder (MDD) with different appetite changes. Findings reveal distinct biological pathways linked to hyperphagic and hypophagic MDD, offering insights into depression subtypes.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Major Depressive Disorder (MDD) is a complex condition with varied symptoms.
- Appetite changes, such as hyperphagia (increased appetite) and hypophagia (decreased appetite), define distinct MDD endophenotypes.
- These appetitive phenotypes are linked to comorbidities and differing clinical outcomes, but their underlying biological mechanisms are poorly understood.
Conclusions:
- Peripheral blood RNA profiling can identify biological correlates of appetitive MDD endophenotypes.
- Distinct molecular signatures exist for hyperphagic and hypophagic MDD.
- Further research into these pathways may lead to targeted treatments for depression subtypes.
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