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Updated: Jul 9, 2025

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Published on: December 21, 2019
Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus
Lucas J Adams1, Saravanan Raju1, Hongming Ma1,2
1Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Eastern equine encephalitis virus (EEEV) uses multiple sites on the very low-density lipoprotein receptor (VLDLR) for entry. A designed VLDLR decoy neutralizes EEEV infection and protects mice.
Area of Science:
- Virology
- Structural Biology
- Immunology
Background:
- The very low-density lipoprotein receptor (VLDLR) facilitates the entry of alphaviruses, including Eastern equine encephalitis virus (EEEV) and Semliki Forest virus (SFV).
- VLDLR is characterized by eight LDLR type A (LA) domains, crucial for viral interactions.
Conclusions:
- EEEV employs a complex, multi-site interaction strategy with VLDLR for viral entry.
- Targeting VLDLR-virus interactions offers a promising therapeutic avenue for EEEV.
- The developed VLDLR decoy receptor demonstrates potential as a novel antiviral treatment.
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