Related Experiment Video
Updated: Jul 9, 2025
12:56
Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
Published on: December 19, 2017
7.8K
Acetylcholine Promotes Directionally Biased Glutamatergic Retinal Waves
Kathy Zhang1,2, Ashley Su1, Yixiang Wang1
1Department of Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, United States.
Biorxiv : the Preprint Server for Biology
|November 28, 2023
Summary
Cholinergic and glutamatergic systems interact to guide developing mouse vision. Cholinergic signaling is crucial for Stage III retinal waves
Area of Science:
- Neuroscience
- Developmental Biology
- Visual System Development
Background:
- Spontaneous retinal waves guide visual system self-organization before eye-opening.
- Retinal waves transition from cholinergic (Stage II) to glutamatergic (Stage III) drive.
- A temporal-to-nasal propagation bias is observed in late Stage II and early Stage III waves.
Conclusions:
- Cholinergic and glutamatergic systems are interdependent for normal visual circuit development.
- Cholinergic signaling, particularly through specific nicotinic receptors, dictates the directional bias of developing retinal waves.
