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Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Structural and biochemical requirements for secretory component interactions with dimeric Immunoglobulin A

Sonya Kumar Bharathkar1,2,3, Beth M Stadtmueller1,2,3

  • 1Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, Illinois 61801 USA.

Biorxiv : the Preprint Server for Biology
|November 28, 2023
PubMed
Summary

Secretory Immunoglobulin A (SIgA) is crucial for mucosal immunity. This study identifies key residues in secretory component (SC) that bind dimeric IgA (dIgA), revealing mechanisms of SIgA transport and function.

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