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Related Experiment Video

Updated: Jul 9, 2025

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury.

Andrew R Morris, Erwin K Gudenschwager Basso, Miguel A Gutierrez-Monreal

    Biorxiv : the Preprint Server for Biology
    |November 28, 2023
    PubMed
    Summary

    Traumatic brain injury (TBI) in mice caused chronic sleep disturbances and altered circadian rhythms. This new rodent model reveals lasting effects on sleep and behavior after injury.

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    A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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    Area of Science:

    • Neuroscience
    • Sleep Medicine
    • Traumatic Brain Injury Research

    Background:

    • Chronic sleep and wake disturbances are common after traumatic brain injury (TBI) but underlying mechanisms remain unclear.
    • There is a need for animal models to study lifelong sleep disturbances following TBI.

    Approach:

    • A chronic TBI rodent model was developed using repetitive midline fluid percussion injury (rmFPI) in adult mice.
    • Sleep/wake behavior was monitored non-invasively using the PiezoSleep system before and monthly after injury.
    • Neuropathology, including brain tissue loss and glial marker expression, was assessed.

    Key Points:

    • TBI mice showed significantly reduced sleep duration in both light and dark phases starting three months post-injury.
    • TBI mice exhibited altered circadian locomotor activity, reduced anxiety-like behavior, and physiological changes (weight, body composition).
    • Chronic neuropathology, including hypothalamic gliosis, was observed in TBI mice.

    Conclusions:

    • This study establishes a chronic TBI rodent model with persistent sleep/wake and circadian phenotypes.
    • The findings highlight a critical time window for TBI pathology and associated behavioral changes.
    • This model can be used to investigate molecular mechanisms of chronic sleep disturbances after TBI.