Microemulsions, nanoemulsions and emulgels as carriers for antifungal antibiotics

Area of Science:

• Dermatology
• Pharmaceutics
• Infectious Diseases

Background:

• Fungal skin diseases are the most common infectious disease, affecting up to 25% of the global population.
• Conventional antifungal drugs face challenges including poor solubility, low permeability, side effects, and reduced efficacy.
• Novel drug delivery systems present a promising strategy to enhance antifungal treatment effectiveness.

Purpose of the Study:

• To review microemulsions, nanoemulsions, and emulgels as advanced topical delivery systems for antifungal agents.
• To highlight the potential of these novel formulations in overcoming the limitations of conventional antifungal therapies.
• To discuss the translational value of these delivery systems for human fungal infection treatment.

Main Methods:

• Review of existing literature on microemulsions, nanoemulsions, and emulgels for topical antifungal drug delivery.
• Analysis of pharmacokinetic profiles and efficacy of novel delivery systems compared to conventional formulations.
• Exploration of the potential applications and development pathways for these advanced systems.

Main Results:

• Microemulsions, nanoemulsions, and emulgels demonstrate potential for improved topical delivery of antifungal drugs.
• These novel systems can enhance solubility, permeability, and efficacy while potentially reducing side effects.
• The reviewed formulations show promise in addressing the pharmacokinetic limitations of current antifungal treatments.

Conclusions:

• Novel delivery systems like microemulsions, nanoemulsions, and emulgels are valuable for topical antifungal therapy.
• These advanced formulations offer a promising approach to improve treatment outcomes for widespread fungal skin infections.
• Further development and clinical translation of these systems could significantly benefit patients with fungal infections.