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LSD1 in drug discovery: From biological function to clinical application

Hui-Min Liu1, Ying Zhou1, He-Xiang Chen1

  • 1State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Medicinal Research Reviews
|November 28, 2023
PubMed
Summary

Lysine-specific demethylase 1 (LSD1) regulates gene transcription and is upregulated in cancers. Inhibitors targeting LSD1 are in clinical trials, offering potential therapeutic strategies.

Keywords:
LSD1biological activityclinical trialinhibitor

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